Detective Lindsay Boxer and her friend Yuki Castellano are out shopping with Yuki's mother Keiko when Keiko drops in the middle of the busy street. It looks like she's had a stroke and Yuki starts to panic. She is rushed to the San Francisco Medical Center. Over drinks that evening at Susie's; with her friends in the Women's Murder Club; Lindsay learns of a huge malpractice suit against the San Francisco Medical Center. In the last few years; dozens of patients who were admitted to the emergency room seemed to recover and then died suspicious deaths. Is Yuki's mother safe? In a place where the lives of patients are quite literally in others hands; will Lindsay and her friends be able to establish who they can trust?